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Search Results for " Bcl-2 Family "

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阻害剤

天然化合物

315

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T17018	TCPOBOP		BCL
	TCPOBOP is a constitutive androstane receptor agonist that induces robust hepatocyte proliferation and hepatomegaly. TCPOBOP decreases Fas-induced murine liver injury by altering Bcl-2 proteins.		BCL
T11944	Maritoclax	Marinopyrrole A	BCL
	Maritoclax (Marinopyrrole A) (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor, shows >8 fold selectivity than BCL-xl (IC50 > 80 μM),with an IC50 value of 10.1 μM.		BCL
T12824L	S55746	BLC201	BCL
	S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).		BCL
T5346	S63845		BCL
	S63845 is a selective MCL-1 inhibitor(Kd: 0.19 nM)		BCL
T14376	AZD4320		BCL
	AZD4320 is an inhibitor of BH3-mimicking dual BCL2/BCLxL. For KPUM-MS3, KPUM-UH1, and STR-428 cells, the IC50s values are 26 nM, 17 nM, and 170 nM , respectively.		BCL
T14071	A-385358		BCL
	A-385358 is a selective Bcl-xL inhibitor with Kis of 0.80 nM for Bcl-xL and 67 nM for Bcl-2, respectively.		BCL
T6650	Sabutoclax	BI-97C1	BCL
	Sabutoclax (BI-97C1)(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.		BCL
T1980	HA14-1		BCL
	HA14-1, a Bcl-2/Bcl-XL antagonist, is a non-peptidic ligand of a Bcl-2 surface pocket (IC50: ~9 μM).		BCL
T14561	BI-3812		BCL
	BI-3812 is an inhibitor of BCL6. Which inhibiting the BTB domain of BCL6 (IC50: 3 nM). BI-3812 also has antitumor activity.		BCL
T2453	BAM7		BCL
	BAM 7 is a direct and specific activator of proapoptotic Bax (EC50: 3.3 μM).		BCL
T5408	BI-3802		BCL
	BI-3802, a highly potent BCL6 degrader, targets and inhibits the Bric-à-brac (BTB) domain of BCL6, exhibiting an IC50 value of ≤3 nM. It induces polymerization of BCL6 and facilitates its degradation in a manner dependen...		BCL
T5108	ML311		BCL
	ML311 is a selective inhibitor of the Mcl-1/Bim interaction.		BCL
T6749	A-1331852		BCL
	A-1331852 is a potent and selectiveBCL-XL inhibitor and may be useful in the treatment of cancer, immune and autoimmune diseases.		BCL
T4089	FX1		Apoptosis , BCL
	FX1 is an effective and selective BCL6 inhibitor (IC50: 35 μM).		Apoptosis , BCL
T2632	A-1210477		Apoptosis , BCL
	A-1210477 is an effective and specific MCL-1 and Bcl-2 inhibitor (Ki/IC50: 0.454/26.2 nM).		Apoptosis , BCL
T14834	BT2		BCL
	BT2, a BCKDC kinase (BDK) inhibitor, exhibits an IC50 of 3.19 μM and functions as a potent, selective Mcl-1 inhibitor with a Ki value of 59 μM. Its interaction with BDK induces helix movements in the N-terminal domain, l...		BCL
T6281	TW-37	TW 37	BCL
	TW-37 is an nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 (Ki: 0.29/1.11/0.26 μM).		BCL
T2099	ABT-737		Mitophagy , BCL , Autophagy
	ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).		Mitophagy , BCL , Autophagy
T6034	UMI-77	UMI77,UMI 77	BCL
	UMI-77, a specific Mcl-1 inhibitor (Ki: 490 nM), has selectivity over other members of Bcl-2 family.		BCL
T2101	Navitoclax	ABT-263	BCL
	Navitoclax (ABT-263) is a Bcl-2 inhibitor that binds to Bcl-xL, Bcl-2, and Bcl-w proteins (Ki<1 nM) with potent and oral activity. Navitoclax has antitumor activity and induces apoptosis.		BCL
T3940	CID5721353	BCL6 inhibitor	Apoptosis , BCL
	CID5721353 (BCL6 inhibitor) is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor) that disrupts BCL6/corepressor complexes in vitro and in vivo, and was shown to bind the critical site within the BTB groove.		Apoptosis , BCL
T6748	A-1155463	A 1155463,A1155463	BCL
	A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM).		BCL
T6778	BDA-366		BCL
	BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies its antiapoptotic function, thereby transforming it into a pro-ap...		BCL
T5210	BAI1		Apoptosis , BCL
	BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM).		Apoptosis , BCL
T5104	BTSA1		Apoptosis , BCL
	BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.		Apoptosis , BCL
T15771	Lobaplatin	D-19466	DNA Alkylation
	Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent which shows activity for a variety of tumour types and is a ...		DNA Alkylation
T12041	MIM1	Inhibitor of Mcl-1	BCL
	MIM1 (Inhibitor of Mcl-1) is an myeloid cell factor 1 (Mcl-1) inhibitor.		BCL
T16028	IMB-XH1	Mcl1-IN-2	BCL , Antibacterial
	IMB-XH1 (Mcl1-IN-2) is a myeloid cell factor 1 (Mcl-1) inhibitor.		BCL , Antibacterial
T12186	Navitoclax-piperazine	ABT-263-piperazine	BCL , Ligands for Target Protein for PROTAC
	Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL).		BCL , Ligands for Target Protein for PROTAC
T6275	Obatoclax Mesylate	Obatoclax,GX15-070	BCL , Parasite , Autophagy
	Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3.		BCL , Parasite , Autophagy
T2119	Venetoclax	GDC-0199,ABT 199,ABT-199,ABT199	BCL , Autophagy
	Venetoclax (ABT-199) is a Bcl-2 inhibitor (Ki<0.01 nM) with potent, selective, and orally active properties. Venetoclax has a 3-order-of-magnitude lower affinity for Bcl-xL and Bcl-W (Kis=48/245 nM). Venetoclax induces a...		BCL , Autophagy
T1493	BH3I-1	BHI1	BCL , E1/E2/E3 Enzyme
	BH3I-1 (BHI1) is a Bcl-2 antagonist.		BCL , E1/E2/E3 Enzyme
T6941	PI-1840	PI 1840	PARP , Proteasome
	PI-1840（IC50 = 27 nM）is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).		PARP , Proteasome
T9083	TC11	CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11	BCL , Caspase , CDK
	TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.		BCL , Caspase , CDK
T39910	Desmorpholinyl Navitoclax-NH-Me	Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me	BCL
	Desmorpholinyl Navitoclax-NH-Me (Desmorpholinyl ABT-263-NH-Me) is a Bcl-xL inhibitor, which can be employed alongside a CRBN ligand to synthesize XZ739, a PROTAC BCL-XL degrader [1] [2].		BCL
T1979	AVN-944	VX-944	Dehydrogenase
	AVN-944 (VX-944)(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.		Dehydrogenase
T9945	MNK8	3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione	STAT
	MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1].		STAT
T6396	(R)-(-)-Gossypol acetic acid	(-)-Gossypol acetic acid,AT-101 (acetic acid),(R)-Gossypol acetic acid,AT101,AT101 acetate	BCL , Autophagy
	(R)-(-)-Gossypol acetic acid (AT101 acetate) , the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID. Phase 2.		BCL , Autophagy
T1406	Amantadine hydrochloride	1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride	Dopamine Receptor , Influenza Virus
	Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.		Dopamine Receptor , Influenza Virus
T9014	SKI-178		Apoptosis , S1P Receptor
	SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ...		Apoptosis , S1P Receptor
T16328	Nitroaspirin	NCX 4016	Apoptosis , COX
	Nitroaspirin (NCX 4016) is a nitric oxide donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin induces significant induction of cell cycle arrest and apoptosis...		Apoptosis , COX
T24953	YCW-E11
	YCW-E11 is an antiapoptotic Bcl-2 family proteins inhibitor.
T26789	BH3I-2'	BH3I2',BH3I 2'
	BH3I-2' is a cell-permeable BH3 mimetic. BH3I-2' induces apoptosis by specifically preventing BH3 domain-mediated interactions between pro-apoptotic and anti-apoptotic members of the Bcl-2 family, thereby blocking the in...
T74138	PROTAC Bcl-xL degrader-2
	PROTAC Bcl-xL degrader-2, based on von Hippel-Lindau ligand, is a potent degrader of Bcl-xL (a Bcl-2 family member), demonstrating an IC 50 of 0.6 nM.
TP1836	BMf-BH3
	BMf-BH3 belongs to the Bcl-2 apoptosis mediator family. This peptide belongs to the Bcl-2 apoptosis mediator family. Bmf is a key player in histone deacetylase (HDAC) inhibition, which alters the balance between deacetyl...
T80038	Bim BH3
	Bim BH3 is a bioactive peptide that belongs to the pro-apoptotic Bcl-2 family of proteins.
T71456	Navitoclax dihydrochloride
	Navitoclax dihydrochloride is a synthetic small-molecule antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity.
T40230	Mcl-1 inhibitor 6
	Mcl-1 inhibitor 6 is a potent, orally active chemical compound that selectively inhibits the myeloid cell leukemia 1 (Mcl-1) protein, with a high affinity (K d = 0.23 nM) and binding activity (K i = 0.02 μM). This compou...
T21786	Apogossypolone (ApoG2)
	Apogossypolone (ApoG2) is a semi-synthesized derivative of gossypol which is a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins with K i values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-X L, respe...
T39909	XZ739	XZ739
	XZ739 is a Cereblon-dependent PROTAC BCL-XL degrader, targeting a member of the Bcl-2 family, with a DC50 value of 2.5 nM in MOLT-4 cells after 16 hours of treatment. Additionally, XZ739 elicits cell death via caspase-me...

Compounds

Synonym: Marinopyrrole A

Target: Apoptosis, BCL

A-1210477

T2632

Synonym:

Target: Apoptosis, BCL

Target: Mitophagy, BCL, Autophagy

UMI-77

T6034

Synonym: UMI77,UMI 77

Synonym: BCL6 inhibitor

Target: Apoptosis, BCL

A-1155463

T6748

Synonym: A 1155463,A1155463

Target: Apoptosis, BCL

BTSA1

T5104

Synonym:

Target: Apoptosis, BCL

Lobaplatin

T15771

Synonym: D-19466

Target: DNA Alkylation

MIM1

T12041

Synonym: Inhibitor of Mcl-1

Target: BCL, Antibacterial

Navitoclax-piperazine

T12186

Synonym: ABT-263-piperazine

Target: BCL, Ligands for Target Protein for PROTAC

Obatoclax Mesylate

T6275

Synonym: Obatoclax,GX15-070

Target: BCL, Parasite, Autophagy

Venetoclax

T2119

Synonym: GDC-0199,ABT 199,ABT-199,ABT199

Target: BCL, Autophagy

BH3I-1

T1493

Synonym: BHI1

Target: BCL, E1/E2/E3 Enzyme

PI-1840

T6941

Synonym: PI 1840

Target: PARP, Proteasome

TC11

T9083

Synonym: CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11

Target: BCL, Caspase, CDK

Desmorpholinyl Navitoclax-NH-Me

T39910

Synonym: Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me

Target: Dehydrogenase

MNK8

T9945

Synonym: 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione

Target: STAT

(R)-(-)-Gossypol acetic acid

T6396

Synonym: (-)-Gossypol acetic acid,AT-101 (acetic acid),(R)-Gossypol acetic acid,AT101,AT101 acetate

Target: BCL, Autophagy

Amantadine hydrochloride

T1406

Synonym: 1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride

Target: Dopamine Receptor, Influenza Virus

SKI-178

T9014

Synonym:

Target: Apoptosis, S1P Receptor

Nitroaspirin

T16328

Synonym: NCX 4016

Target: Apoptosis, COX

Synonym: BH3I2',BH3I 2'

Target:

PROTAC Bcl-xL degrader-2

Navitoclax dihydrochloride

Apogossypolone (ApoG2)

カタログ番号	製品名	別名	ターゲット
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
T8213	Isolinderalactone		NOS , STAT
	Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.		NOS , STAT
TN1406	Dihydrokaempferol	Aromadendrin	Apoptosis , BCL
	Dihydrokaempferol (Aromadendrin) is a natural product. It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression, possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory ...		Apoptosis , BCL
T7979	2-Hydroxychalcone	2-(2-Hydroxybenzal)Acetophenone	Apoptosis , BCL , Others , NF-κB
	2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated.It can inhibit invasion of triple negative breast cancer cells.		Apoptosis , BCL , Others , NF-κB
T6518	Gossypol	Pogosin,BL 193,NSC 56817	BCL , Dehydrogenase
	Gossypol (BL 193) Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.		BCL , Dehydrogenase
T6S0052	Chelerythrine	Toddalin,Broussonpapyrine,Cheleritrine	Apoptosis , BCL , PKC , Autophagy
	1. Chelerythrine (Broussonpapyrine) may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. Chelerythrine has potential antiprolifera...		Apoptosis , BCL , PKC , Autophagy
T3419	Chelerythrine chloride		Apoptosis , BCL , PKC , Autophagy
	Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.		Apoptosis , BCL , PKC , Autophagy
T5S2358	Dehydrocorydaline	Dehydrocorydalin,13-Methylpalmatine	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz...		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
T10990	Dehydrocorydaline chloride	13-Methylpalmatine chloride	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
T2S2362	Dehydrocorydaline nitrate		BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a...
T6185	Gambogic Acid	Beta-Guttiferrin,Guttatic Acid,Guttic Acid	BCL , Autophagy
	Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 ...		BCL , Autophagy
T3344	Ciwujianoside B	yemuoside YM,acanthopanax senticosides B,Ciwujianoside-B	BCL , Others
	Ciwujianoside B (acanthopanax senticosides B) is the main component of Acanthopanax, can relieve fatigue, enhance memory, and improve human cognition.		BCL , Others
T5679	(E)-Ferulic acid	trans-Ferulic acid,(E)-Coniferic acid	BCL , Ferroptosis , Wnt/beta-catenin , Endogenous Metabolite
	(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pr...
T2730	Gossypol (acetic acid)	(±)-Gossypol-acetic acid,Pogosin,AT101,Gossypol acetic acid	BCL
	Gossypol acetic acid (AT101), a polyphenolic compound isolated from cottonseeds, binds with Bcl-2, Bcl-xL, Mcl-1, and does not inhibit BIR3 domain and BID.		BCL
T2163	Dihydrocapsaicin	CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others , TRP/TRPV Channel
	Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an...		Others , TRP/TRPV Channel
T2851	Daphnetin	7,8-Dihydroxycoumarin,Daphnetol	EGFR , PKA , PKC , Parasite , Autophagy
	Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-...		EGFR , PKA , PKC , Parasite , Autophagy
T4085	Paris saponin VII	Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis , BCL , Others , PARP , p38 MAPK , Akt , Caspase , P-gp , Autophagy
	Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
T7060	Amantadine	1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine	Others
	Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake.		Others
T3867	Alpinetin	(-)-alpinetin	BCL , PPAR
	Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to the chemotherapeutic agent CDDP. Alpinetin has strong anti-he...		BCL , PPAR
T6S1418	Praeruptorin C		Antioxidant , Calcium Channel
	1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors ...		Antioxidant , Calcium Channel
T2823	Crocin	Gardenia Yellow,Alpha-Crocin	Others
	Crocin (Gardenia Yellow) is a water-soluble carotenoid pigment of saffron (Crocus sativus L. ) that has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne...		Others
T3923	Calycosin	Cyclosin,3'-Hydroxyformononetin	Apoptosis , Tyrosinase
	Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c...		Apoptosis , Tyrosinase
T6S0735	Flavokawain B	Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone	Apoptosis , Others
	1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, in...		Apoptosis , Others
TN4271	Isochamaejasmine		ERK , BCL , PARP , p38 MAPK , Caspase , PKC , Antifection
	Isochamaejasmine, isolated from S. chamaejasme L., inhibits NF-κB activation. Isochamaejasmine induces leukemia cell apoptosis by inhibiting the activity of Bcl-2 family proteins and can be used in anti-cancer research.		ERK , BCL , PARP , p38 MAPK , Caspase , PKC , Antifection
T11009	Destruxin B		Others
	Destruxin B is a cyclic peptide with insecticidal and anticancer activity isolated from the insect pathogenic fungus Metarhizium isopliae. Destruxin B induces apoptosis of human non-small cell lung cancer cells through t...		Others

天然物製品

Jaceosidin

T3824

Synonym:

Target: Apoptosis, BCL, COX, UGT

Synonym: Aromadendrin

Target: Apoptosis, BCL

2-Hydroxychalcone

T7979

Synonym: 2-(2-Hydroxybenzal)Acetophenone

Target: Apoptosis, BCL, Others, NF-κB

Gossypol

T6518

Synonym: Pogosin,BL 193,NSC 56817

Target: BCL, Dehydrogenase

Chelerythrine

T6S0052

Synonym: Toddalin,Broussonpapyrine,Cheleritrine

Target: Apoptosis, BCL, PKC, Autophagy

Chelerythrine chloride

T3419

Synonym:

Target: Apoptosis, BCL, PKC, Autophagy

Dehydrocorydaline

T5S2358

Synonym: Dehydrocorydalin,13-Methylpalmatine

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Dehydrocorydaline chloride

T10990

Synonym: 13-Methylpalmatine chloride

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Dehydrocorydaline nitrate

T2S2362

Synonym:

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Gambogic Acid

T6185

Synonym: Beta-Guttiferrin,Guttatic Acid,Guttic Acid

Target: BCL, Autophagy

Ciwujianoside B

T3344

Synonym: yemuoside YM,acanthopanax senticosides B,Ciwujianoside-B

Target: BCL, Others

(E)-Ferulic acid

T5679

Synonym: trans-Ferulic acid,(E)-Coniferic acid

Target: BCL, Ferroptosis, Wnt/beta-catenin, Endogenous Metabolite

Gossypol (acetic acid)

T2730

Synonym: (±)-Gossypol-acetic acid,Pogosin,AT101,Gossypol acetic acid

Target: BCL

Dihydrocapsaicin

T2163

Synonym: CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide

Target: Others, TRP/TRPV Channel

Daphnetin

T2851

Synonym: 7,8-Dihydroxycoumarin,Daphnetol

Target: EGFR, PKA, PKC, Parasite, Autophagy

Paris saponin VII

T4085

Synonym: Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy

Amantadine

T7060

Synonym: 1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine

Target: Others

Alpinetin

T3867

Synonym: (-)-alpinetin

Target: Antioxidant, Calcium Channel

Crocin

T2823

Synonym: Gardenia Yellow,Alpha-Crocin

Target: Others

Calycosin

T3923

Synonym: Cyclosin,3'-Hydroxyformononetin

Target: Apoptosis, Tyrosinase

Flavokawain B

T6S0735

Synonym: Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone

Target: Apoptosis, Others

Isochamaejasmine

TN4271

Synonym:

Target: ERK, BCL, PARP, p38 MAPK, Caspase, PKC, Antifection

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00717	BAG2 Protein, Human, Recombinant (His)	Human	E. coli
	BAG Family Molecular Chaperone Regulator 2 (BAG2) is a member of the Bag family whose members compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. BAG2 contains 1 BAG domain and is...
TMPH-02534	BAG3 Protein, Mouse, Recombinant (His)	Mouse	Yeast
	Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleoti...
TMPH-02535	BAG3 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleoti...
TMPY-02431	BCL-XL Protein, Human, Recombinant (His)	Human	E. coli
	B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibi...
TMPY-02700	BCL2 Protein, Human, Recombinant (His)	Human	E. coli
	BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family a...
TMPY-06842	BMP-4 Protein, Human, Recombinant (E399D)	Human	E. coli
	BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP...
TMPY-04052	IL-17RB Protein, Human, Recombinant (His)	Human	HEK293
	IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF...
TMPJ-00038	IL-7 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 a...
TMPY-03974	Bim Protein, Human, Recombinant (His)	Human	E. coli
	BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. ...
TMPY-02564	BCL-XL Protein, Mouse, Recombinant (aa 1-212, His)	Mouse	E. coli
	B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibi...
TMPK-00636	BID Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Bid, BH3-interacting domain death agonist, was initially cloned based in its ability to interact with both Bcl-2 and Bax. Bid contains only the BH3 domain, which is required for its interaction with the Bcl-2 family prot...
TMPJ-00584	Bc1-w Protein, Human, Recombinant (His)	Human	E. coli
	Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing thre...
TMPY-02065	BID Protein, Mouse, Recombinant (His & GST)	Mouse	E. coli
	The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro...
TMPY-02027	BID Protein, Human, Recombinant	Human	E. coli
	The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro...
TMPJ-01066	CYCS Protein, Human, Recombinant (His)	Human	E. coli
	Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as...
TMPY-00431	BMP-4 Protein, Mouse, Recombinant (rFc)	Mouse	HEK293
	BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP...
TMPY-01824	Caspase-14 Protein, Human, Recombinant (His)	Human	E. coli
	Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses...
TMPY-00352	IL-17RB Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF...
TMPY-03850	IL-17RB Protein, Human, Recombinant (hFc)	Human	HEK293
	IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF...
TMPY-04162	IL-17RB Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF...
TMPY-03471	IL-17RB Protein, Mouse, Recombinant (His)	Mouse	HEK293
	IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF...
TMPY-04706	IL-17RB Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
	IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF...
TMPY-04936	BCL2A1 Protein, Human, Recombinant (His)	Human	E. coli
	B-cell lymphoma 2-related protein A1 (BCL2A1) is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs. Immunohistochemical expression of Wnt11 and BCL2A1 in...
TMPY-04417	DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST)	Human	Baculovirus-Insect Cells
	Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK...
TMPY-00005	FGF-8a Protein, Human, Recombinant	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment...
TMPY-00850	ST2/IL-1 RL1 Protein, Human, Recombinant	Human	HEK293
	IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-00891	Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)	Human	HEK293
	Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is...
TMPY-02358	CD98 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A tr...
TMPY-00748	Nectin-2 Protein, Human, Recombinant	Human	HEK293
	Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein a...
TMPY-01691	Clusterin Protein, Human, Recombinant (CLU34, His)	Human	HEK293
	Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot...
TMPY-02792	GDNF Protein, Human, Recombinant (HEK293)	Human	HEK293
	Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic fact...
TMPY-05288	PLGF/PGF Protein, Human, Recombinant (aa 19-149)	Human	E. coli
	PLGF/PGF Protein, Human, Recombinant (aa 19-149) is expressed in E. coli.
TMPY-02011	CD96 Protein, Human, Recombinant (His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-00871	LAYN Protein, Human, Recombinant (hFc)	Human	HEK293
	Layilin recently characterized as a 55 kDa transmembrane protein with homology to C-type lectins, is present in numerous cell lines and tissue extracts. As one of the adaptor proteins, talin mediates the interactions bet...
TMPY-00341	FGFR3 Protein, Human, Recombinant (alpha IIIb, His)	Human	HEK293
	FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ ...
TMPY-00849	ST2/IL-1 RL1 Protein, Human, Recombinant (hFc)	Human	HEK293
	IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-04116	KRAS Protein,Human,Recombinant(G12C & Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-04844	BTN3A1 Protein, Human, Recombinant (His)	Human	HEK293
	BTN3A1 has the structure of a type I receptor of the Ig superfamily and is part of a family of seven BTN receptors encoded by genes in the MHC. BTN molecules are composed of two Ig domains (IgV, IgC2), a single transmemb...
TMPJ-00850	ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)	Mouse	Human Cells
	ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes....
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TMPY-04356	GSK3B Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It Contains 1 protein kinase domain, and is expressed in the testis, thymus, prostate, and ovary and weakly expressed in the lung, ...
TMPY-02971	CLEC10A Protein, Human, Recombinant (hFc)	Human	HEK293
	CLEC10A, also known as the macrophage galactose-type calcium-type lectins (MGLs; CD301) constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. MGLs/CD301 is ...
TMPY-02820	SDF-1 Protein, Human, Recombinant (isoform a)	Human	E. coli
	The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-04113	KRAS Protein,Human,Recombinant(G12D & Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-05427	CD19 Protein, Human, Recombinant (hFc)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-01199	CD74 Protein, Human, Recombinant (His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05586	CD28H/TMIGD2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	The orthologue of human IGPR-1 is found only in eukaryotes, including primates, the guinea pig, canines, felines, dolphins, bovines, the llama, bats, the common shrew, and horses. Of interest, the IGPR-1 gene is absent i...
TMPY-00751	TrkB Protein, Human, Recombinant (His)	Human	HEK293
	TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kin...
TMPY-02367	Neuropilin-1 Protein, Human, Recombinant (isoform b, His)	Human	HEK293
	Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is...
TMPY-01935	C-Kit Protein, Human, Recombinant (His)	Human	HEK293
	C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the pr...
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